At least 50 genes in our list are already known to be regulated by DNA methylation, such as those encoding cancer antigens (a set of MAGE and GAGE), H19, S100A4, IGFBP4, UCHL1, COL1A2, CLU, FN1, and TGFBI (Figure 2B). The gene discussed is TGFBI; the disease is cancer.