LGALS3 and fungal infectious disease: Because gal3−/− mice, during P. brasiliensis infection, develop a Th2-polarized immune response and succumbed to infection, we conclude that galectin-3 is central to maintaining the intermediate resistance of C57BL/6 mice to P. brasiliensis, and the deletion of the galectin-3 gene renders mice susceptible to the fungal infection.