PDZK1 and infection: Furthermore, whenPDZK1 was knocked-down in Huh-7 cells using siRNAs, we found that the PDZK1down-regulated cells induced HCV entry and infection-enhancement at levelsidentical to those detected in unmodified Huh-7 cells (Figure S3).Thus, PDZK1 down-regulation had almost no effect on HCV entry, in agreement withthe results of AKL motif deletion.