Expression of hSR-BI in BRL3A-CD81-CLDN1 cells allowed HCVpp entryat titers similar to those detected in PLC/PRF/5 and Hep3B humanhepato-carcinoma cells (Figure1B), used in previous reports [12],[13],[33],[34], and ca. 8-foldlower than those obtained with Huh-7 cells (Figure 1B), which are the most susceptible toHCV entry [12],[13],[14],[33].Of note, co-expression of hCD81, hCLDN1 and/or hSR-BI did not modify total(FigureS1A) or cell surface (Figure S2) expression levels of either ofthese entry factors. Here, CD81 is linked to carcinoma.