As shown in Figure 2C, while BRL3A-CD81-CLDN1 cells couldnot or hardly mediate lipid transfer most likely owing to undetectable SR-BIlevels (FigureS1A and S1B), ectopic expression of hSR-BI in these cells resulted inefficient lipid uptake and efflux, as compared to rat hepatoma Fu5AH cellsexpressing rat SR-BI (Figure S1A and S1B) used as positivecontrols. This evidence concerns the gene CD81 and hepatocellular carcinoma.