HDL, the main ligand of SR-BI, enhances infection of HCVpp [25],[28],[29]and HCVcc [26],[27],[30] inSR-BI-positive human cells that are susceptible to HCV entry like, e.g., Huh-7,HepG2-CD81, PLC/PRF/5, SW13 or Hep3B cells. Here, CD81 is linked to infection.