Third, an essential component of HDL that seems responsible for infection enhancementat the level of HCV membrane fusion is the apolipoprotein C-I (ApoC-I) [28],[35], anexchangeable apolipoprotein that could be transferred from HDL to the HCV membraneduring SR-BI-mediated lipid transfer and could predispose HCV envelope for fusionwith a target membrane, via alterations of its outer phospholipidlayer [35]. The gene discussed is APOC1; the disease is infection.