CLDN1 and infection: Yet, while HCV RNA decreased again by ca. 15-fold in theparental SK-Hep1-CLDN1 cells at 72 hr, the HCV RNA levels increased inSK-Hep1-CLDN1-SR-BI cells at 72 hr vs. 12 hr post-infection but were stronglyreduced when such target cells were treated during 72 hr with HCV replicationinhibitors (BILN2061, an NS3 protease inhibitor, or2′-C-methyl-adenosine, an NS5B polymerase inhibitor) (Figure 2A).