In multivariate analysis, the relationship between moderate lifetime alcohol consumption and FMD remained significant after adjusting for sex, race-ethnicity, body mass index, diabetes mellitus, CAD, Framingham risk score and medication use (cholesterol lowering agents, aspirin, insulin, oral hypoglycemic agents, ACE inhibitors, beta-blockers, calcium channel blockers and diuretics) (adjusted OR 1.8, 95%CI 1.1–3.0 p = 0.03). Here, INS is linked to coronary artery disorder.