LCK and leukemia: In tax transgenic mouse models, the mice develop a wide range of tumors such as neurofibrosarcomas, mesenchymal tumors, and mammary adenomas, or even skeletal abnormalities including osteolytic bone metastases [20-27]; however, no leukemias or lymphomas were identified except in three models, which used respectively the granzyme B promoter [28], Lck proximal promoter [29] and Lck distal promoter [30].