Prior reports have evaluated in a limited setting one or more of the gene loci evaluated by this report including, katG, ahpC, regulatory region of inhA, and the ORF region of inhA. However, none of these studies have comprehensively catalogued mutations in all of these loci in a single study and testing large numbers of clinical samples from TB prevalent regions such as, South America, nor have they correlated the identified mutations with INH MIC levels. Here, INHA is linked to tuberculosis.