Transcription factor 7-like 2 (TCF7L2) gene spans a 215,863 bases region on chromosome 10q25.3 [46] (114700201–114916063, NCBI build 36.2), and its product is a high-mobility box-containing transcription factor that has a role in activating many genes downstream of the Wnt signaling pathway and in T2DM [47-50]. Here, TCF7L2 is linked to type 2 diabetes mellitus.