CD4 and neoplasm: Among these CD3+CD45+ TILs, we observed a decrease between the early/intermediate and the late time point in the proportion of TILs that were CD4+ (76.5% vs. 47.5%, P = 0.0003), suggesting that alternate T cell subsets may be infiltrating the tumor microenvironment, such as CD8+ CTLs or NK T cells (Figure 4B).