We show that these profound effects correlate with focal induction of Hedgehog (Hh) pathway activity within subpopulations of stromal and basal (K14+/p63+) cells found exclusively within the Wnt-1 tumor microenvironment, as well as, in and around melanocytic hyperplastic nevi, which form a hallmark of all MMTV-Wnt1 mammary glands. This evidence concerns the gene KRT14 and neoplasm.