SERPINF1 and age-related macular degeneration: Table 3 shows PEDF genotype distribution in AMD patients and controls. In both groups, the observed genotype distributions were in line with those predicted by the Hardy–Weinberg equilibrium. PEDF genotype and allele frequencies were not significantly different between AMD patients and controls (Table 3). The two promoter polymorphisms, −5736T>C (rs12150053) and −5304C>T (rs12948385), were in complete association.