SERPINF1 and age-related macular degeneration: In 2005, Yamagishi et al. [22] proposed the hypothesis that a PEDF gene polymorphism, which is characterized by a methionine to threonine substitution at amino acid position 72 of PEDF (PEDF Met72Thr [PEDF 311T>C], rs1136287) [23], might be a genetic marker for AMD.