RUNX3 and colorectal carcinoma: Other studies have shown methylation-related transcriptional silencing of RUNX3 expression in gastric (Li et al, 2002; Waki et al, 2003), colorectal (CRC) (Goel et al, 2004; Ku et al, 2004) and oesophageal squamous cell (Sakakura et al, 2007) carcinomas.