To gain insight into the role of Apollon in breast cancer cell survival, we used an RNAi-based strategy to downregulate its expression in three human breast cancer cell lines, characterised by a different TP53 gene status: ZR75.1 and MCF-7 cells bearing wild-type p53 and MDA-MB-231 cells carrying mutant p53. This evidence concerns the gene BIRC6 and breast carcinoma.