In this context, it has been reported recently that apoptosis induction after transduction of HT-1080 human fibrosarcoma cells with an oncolytic adenovirus, expressing a short hairpin RNA against Apollon, was mediated by the proteolytic activation of caspase-8 and caspase-3 (Chu et al, 2008). The gene discussed is CASP3; the disease is fibrosarcoma.