To examine whether such an effect of YC-1 was responsible for the best therapeutic benefit of our optimal treatment regimen in Figure 5, we performed immunohistochemical analyses for functional blood vessels and for tumour hypoxia (Figure 8) at 5 days after ionising radiation of each treatment regimen applied in Figures 4, 5 and 6 (Figure 8A). This evidence concerns the gene RBMS1 and neoplasm.