Although this result is in line with one previous study showing specific HIF-1α staining in 29% of T1 tumours (Sumiyoshi et al, 2006), two other articles reported strikingly different results (HIF-1α positivity in 68 and 100% of T1 tumours) (Urano et al, 2006; Cabuk et al, 2007). The gene discussed is HIF1A; the disease is neoplasm.