To explore whether mifepristone can inhibit the growth of ovarian cancer cells regardless of their p53 genetic statuses, we studied the response to mifepristone of OV2008 cells that express wild type p53 [30], Caov-3 cells which express an mRNA carrying a point mutation that results in a chain termination signal likely to generate a truncated peptide not detected by Western blot [31,32], and SK-OV-3 cells carrying a deletion of a single nucleotide as a consequence of which no p53 mRNA transcripts are expressed [31,33,34]. This evidence concerns the gene TP53 and ovarian carcinoma.