Finally, the cell death process triggered by mifepristone in the three ovarian cancer cell lines was associated with activation of caspase-3 marked by the cleavage of full-length pro-caspase-3 into 17 and 19 kDa fragments, which paralleled the cleavage of the caspase-3 downstream substrate PARP to the 89 kDa fragment (Figure 5E). This evidence concerns the gene CASP3 and ovarian carcinoma.