Supporting this concept, in a study conducted utilizing the 60 cancer cell lines of the National Cancer Institute anticancer drug screen program, the majority of clinically active agents, including alkylating agents, antimetabolites, and topoisomerase inhibitors, tended to exhibit growth suppression more in the cell lines with normal p53 status than in the cell lines with mutant p53 status, with the exception of the anti-mitogenic agents [33]. The gene discussed is TP53; the disease is cancer.