The selection of this composite outcome was based on two independent considerations: i) the same pathophysiological origin of both outcomes (i.e., death of cardiac origin and new-onset HF); ii) analyses by individual outcomes (either death or new-onset HF) was not possible given small sample size, while the composite outcome has allowed increasing the power to detect significant differences in TRAIL levels between groups. This evidence concerns the gene TNFSF10 and hydrops fetalis.