Figure 4 shows representative plots of protein intensities of the four most significant proteins are shown: PKM2 (q value = 0.003), GLUT1 (q = 0.007), HSP90AA2 (q = 0.008) and L-lactate dehydrogenase B chain (LDHB, q = 0.008) in individual samples of primary and metastatic melanomas. This evidence concerns the gene PKM and metastatic melanoma.