PKM and cancer: Interestingly, all of the listed proteins have been previously implicated as cancer-related, and some have been suggested to be related to metastasis, including pyruvate kinase isozymes M1/M2 (PKM2), glucose transporter isoform 1 (GLUT1), macrophage migration inhibitory factor (MIF), peroxiredoxin-2 (PRDX2), L-lactate dehydrogenase A chain (LDHA), and heat shock protein HSP 90 alpha 2 (HSP90AA2).