PAX3 and osteosarcoma: Pax3 has also been reported to be unable to initiate myogenesis in the human Saos-2 osteosarcoma cell line [42] and mouse endothelial cells line BEND3 [41], and Pax7 is unable to activate myogenesis in the C3H10T1/2 multipotent mesenchymal cell line [43].