Switching from premix to glargine was associated with an increase in the mean total (glargine + prandial) daily insulin dose in the type 2 diabetes cohort (from 0.67 ± 1.35 U/Kg to 0.88 ± 1.33 U/Kg, p < 0.001) but a slight decrease in the type 1 cohort (from 1.04 ± 2.51 U/Kg to 0.98 ± 2.58 U/Kg, p < 0.001) (Figure 1D). This evidence concerns the gene INS and type 2 diabetes mellitus.