In a retrospective sub-analysis of the AT.LANTUS (A Trial comparing Lantus Algorithms to achieve Normal blood glucose Targets in subjects with Uncontrolled blood Sugar with type 2 diabetes mellitus) study [16], including 686 patients with type 2 diabetes taking premix at baseline, poorly controlled patients who switched to glargine ± OADs/prandial insulin showed significantly improved glycaemic control and a low incidence of severe hypoglycaemia after 6 months on treatment. Here, INS is linked to Hypoglycemia.