This may include more aggressive titration with insulin glargine (in the current analysis glargine treatment had no significant effect on weight despite a moderate increase for the type 1 patients suggesting suboptimal treatment), greater use of OAD therapy in patients with type 2 diabetes (only 38% were receiving OAD therapy at baseline and 35% at 12 months), additional doses of prandial insulin and the use of educational programs [16,35-37]. Here, INS is linked to type 2 diabetes mellitus.