PRNP and Creutzfeldt Jacob disease: Neuropathological examination of affected brains revealed synaptic type PrP deposits in the cortex and thalamic nuclei of iatrogenic CJD-inoculated Tg23 and Tg49 mice (data not shown), and this pattern of neuropathology closely resembled that produced in both transgenic lines by IPD E200K-129MM inoculum (I1091) (Fig. 2g, j).