In recent years, with the identification of lymphatic endothelial growth factor-C (VEGF-C), VEGF-D and lymphatic endothelial markers including LYVE-1, VEGFR-3 and podoplanin, lymphangiogenesis has become one of the highlights in the field of metastasis in NSCLC. This evidence concerns the gene VEGFD and non-small cell lung carcinoma.