To best of our knowledge, there are no previous reports on possible correlations between 18F-FDG uptake and CCND1 or TP53 status in HNSCC, although similar studies have been carried out on other tumours [29,30], demonstrating a correlation between TP53 overexpression and higher 18F-FDG uptake [30]. Here, TP53 is linked to head and neck squamous cell carcinoma.