To address the function of EGFR-Ras and PI3K in glioma, we analyzed the genetic basis of glial pathogenesis in our repo>dEGFRλ;dp110CAAX model, as this model shows robust neoplasia, similarity to human tumor genotypes, and sensitivity to dEGFR and dPTEN gene dosage (data not shown). This evidence concerns the gene EGFR and neoplasm.