Interestingly, the variability in the severity of epilepsy and cognitive impairment in EFMR is reminiscent of what is observed in GEFS+ families (generalized epilepsy with febrile seizures plus, # MIM# 604233), an autosomal dominant condition that also associates febrile seizures with epilepsy of variable types and severity, and which is associated in ∼10–15% of the families with missense mutations in SCN1A[10]. The gene discussed is SCN1A; the disease is Febrile seizure (within the age range of 3 months to 6 years).