Three haplotypes were >1% frequency, the most common two haplotypes (1 and 2) differed at all SNPs, a third haplotype (3) was distinguished from the most common haplotype (1) by a single SNP upstream of HECTD2. Increased risk of vCJD was associated with haplotype 2, possessing rs12249854A, but the extensive LD prevented us from identifying the functional SNP. This evidence concerns the gene HECTD2 and variant Creutzfeldt-Jakob disease.