For this phenomenon, we supposed that hyperglycemia could result in a higher content of intracellular DAG in the cardiomyocytes, leading to increased expression and activity of PKC-α, PKC-β2, then inducing over-expression of NF-κB via PKC-IKK-NF-κB signal transduction pathway[35]. The gene discussed is PRRT2; the disease is Hyperglycemia.