In our research we found that the cardiomyocytes cultured in high glucose levels showed increased expression and activity of PKC-α, PKCβ2, as reflected by the higher protein expression of PKC-α, PKC-β2, p-PKC-α, p-PKC-β2 when examined by western blot, which was in agreement with the cellular defects induced in the cardiomyocytes by hyperglycemia. Here, PRKCA is linked to Hyperglycemia.