Studies have found that activation of NF-κB may function as a causal event in the cardiac hypertrophic response of cardiomyopathy, as modeled in cultured cardiomyocytes and that NF-κB inhibition could attenuate or block the hypertrophy of cultured cardiomyocytes[13,14]. Here, NFKB1 is linked to cardiomyopathy.