BCL2L1 and infection: Two weeks post-infection with Ad-Cre-GFP, the levels of Bcl-x protein within the cell population were reduced by approximately 75–80% (Figure 8A), likely reflecting recombination of the Bcl-x gene in the majority of cells; serum-starved cells +/−Cre were seeded into the upper chambers of porous transwell inserts either uncoated or Matrigel-coated to assess the effect of loss of Bcl-x expression on migration and invasion, respectively.