To substantiate the effect of loss of Bcl-x on invasion, cancer cells with wild-type or deleted Bcl-x (βTC-Bcl-x-wt or βTC-Bcl-x-knockout [KO]) were generated by deriving β-tumor cell lines (“βTC”) from tumors of RIP1-Tag2; Bcl-xfl/fl mice, and infecting the cells with adenoviruses that do or do not express Cre (Ad-Cre-GFP or Ad-GFP). Here, BCL2L1 is linked to neoplasm.