Additionally, Taqman analysis of the same tumor cDNAs for up-regulation of members of the IAP class of anti-apoptotic proteins (CIAP1, CIAP2, Survivin, XIAP, and BRUCE) similarly failed to reveal any significant transcriptional up-regulation of these genes in the Bcl-x-KO tumors (data not shown). This evidence concerns the gene XIAP and neoplasm.