PNLIP and obesity due to melanocortin 4 receptor deficiency: Of the crude drugs contained in Boiogito, it is known that a water extract of Zingiber officinale shows an inhibitory effect on pancreatic lipases and an anti-obesity effect [20]; the ethanol extract lowers TG, lipoprotein and phospholipid levels in hyperlipidemic animals [21] and other components inhibit cholesterol synthesis in the liver [22] In addition, glycyrrhizin, a component of Glycyrrhiza uralensis, is known to improve hyperglycemia, hyperinsulinemia and abnormal glucose tolerance, and so forth, with high-dose administration in KK-Ay mice [23].