Up-regulation of COL1A1 is involved in progression of gastric carcinoma [34] and the methylation status of the COL1A1 promoter is inversely proportional to COL1A1 expression in human cancer cell lines [35], so it is possible that dysregulation of COL1A1 is an effect of the chromatin remodelling capability of E1A. This evidence concerns the gene DHTKD1 and cancer.