A total of 56 molecules are annotated as affecting neoplasia and eight of these are dysregulated over 1.5 fold in Ad12-TC compared to Ad5-TC: down-regulation of ATM, CD19, CD3G, GADD45B, HPSE, TFAP2A and TFPI was observed, whereas levels of EGFR were found to be up-regulated (Additional file 1). The gene discussed is ATM; the disease is neoplasm.