A total of 15 single nucleotide polymorphisms (SNPs) in the peroxisome proliferators-activated receptor γ coactivator 1 α (PPARGC1A) gene (rs2970865, rs2970866, rs4383605, rs2946386, rs2970869, rs17576121, rs2970870, rs7695542, rs2970873, rs2946385, rs12374310, rs7665116, rs2970855, rs2970848, rs8192678) were selected for genotyping in a German HD cohort of more than 400 unrelated patients recruited from the Huntington Center NRW in Bochum. This evidence concerns the gene PPARGC1A and Huntington disease.