It has been demonstrated that coagulation indices includingfibrinogen, von Willebrand factor, and plasminogen activator activity areincreased in BD and Hcy is thought to promote the clotting cascade via severalactions including inactivation of protein C, activation of coagulation factorV, increased vascular smooth muscle cell proliferation, and inhibition ofthrombomodulin [15]. Here, F5 is linked to Behcet disease.