Egr-1overexpression and interaction with the WT1 Wilms' tumour suppressor may beinvolved in the pathogenesis of nephroblastoma [72–74].Further, the bladder and prostate epithelia are contiguous and have commonembryological origin [58, 80, 81],and interestingly, Egr-1 is absolutely required for the development of prostatecancer in a mouse model [82, 83]. Here, WT1 is linked to Wilms tumor.