All 3 tumors were heterozygous for ApcΔ580 mutation and the remaining allele contained a truncation mutation in Apc. Both Gene Set Enrichment analysis (GSEA) and Ingenuity Pathway analysis (IPA) results indicated that mouse tumor profiles have gene sets characteristics of cell cycle, cellular movement and cancer related genes (Dataset S3, S4, S5, and S6). Here, APC is linked to cancer.