Other proteins identified by gene profiling and associated with Alzheimer disease are the low density lipoprotein receptor-related protein 1 (Lrp1) [28], the very low density lipoprotein receptor (Vldlr) [29], the microtubule-associated protein tau (Mapt) [30] and the ionotropic glutamate receptors AMPA1 and AMPA2 (Gria1 and Gria2) [31]. The gene discussed is LRP1; the disease is early-onset autosomal dominant Alzheimer disease.