Other genes causing familial MND include alsin (ALS2) [83,84], senataxin (ALS4) [85], Vesicle associated membrane protein (VAPB, ALS8) [86], Angiogenin [87,88] and a mutation in the p150 subunit of dynactin (DCTN1) [89,90]. This evidence concerns the gene SETX and mild neurocognitive disorder.