MCP-1 secretion was most dramatically reduced in both P and BO cocultures, with the highest reductions of 46% observed in the day 1 cocultures of the BO line (P < 0.05) and 44% in day 2 cocultures of the P line (Fig. 7D; P < 0.001) as compared to cultures of femurs alone. The gene discussed is CCL2; the disease is bronchiolitis obliterans syndrome.