NFKB1 and rheumatoid arthritis: When exposing RASFs to DMARDs (Figure 2), azathioprine, gold sodium thiomalate, and MTX efficiently reverted the RA-induced molecular changes in chondrocytes toward the 'healthy' level; in particular, genes related to inflammation/NF-κB pathway, cytokine/chemokine activity, immune response, proliferation/differentiation, and matrix remodelling were involved.