TGFB1 and rheumatoid arthritis: The DMARDs azathioprine and gold sodium thiomalate, the NSAID piroxicam, and the SAIDs prednisolone and methylprednisolone targeted numerous RA-related pathways involved in cytokine/chemokine activity (cytokine-cytokine receptor interaction and Jak-STAT signalling), matrix remodelling (focal adhesion, TGF-β signalling, and ECM receptor interaction), and lipid metabolism (ether lipid metabolism, biosynthesis of steroids, and arachidonic acid metabolism).