In contrast, the molecules involved in GABA receptor signaling (GABBR1, GABRA1, GABRA5, GABRB1, GABRB3, GABRG2, GAD1, GPR51) and glutamate receptor signaling (GLS, GRIA2, GRIA4, GRM1, GRM5, GRM7, SLC17A6, SLC17A7, SLC1A1) were downregulated in the TGFβ strong response glial tumors. The gene discussed is GRIA2; the disease is glioma.