In contrast, the molecules involved in GABA receptor signaling (GABBR1, GABRA1, GABRA5, GABRB1, GABRB3, GABRG2, GAD1, GPR51) and glutamate receptor signaling (GLS, GRIA2, GRIA4, GRM1, GRM5, GRM7, SLC17A6, SLC17A7, SLC1A1) were downregulated in the TGFβ strong response glial tumors. This evidence concerns the gene GRIA4 and glioma.