In contrast, the molecules involved in GABA receptor signaling (GABBR1, GABRA1, GABRA5, GABRB1, GABRB3, GABRG2, GAD1, GPR51) and glutamate receptor signaling (GLS, GRIA2, GRIA4, GRM1, GRM5, GRM7, SLC17A6, SLC17A7, SLC1A1) were downregulated in the TGFβ strong response glial tumors. The gene discussed is GRM5; the disease is glioma.