IGFBP5 and glioblastoma: Interestingly, the glioblastoma group that showed a strong TGFβ response also showed higher expression of the molecules involved in angiogenesis, such as VEGF, FLT1, NRP1, NRP2, ANGPT2, JAG1, ARTS1, TNFRSF12A. Also the gene expression of a group of insulin-like growth factor binding proteins, including IGFBP2, IGFBP3, IGFBP4, IGFBP5, and IGFBP7 were significantly higher in TGFβ strong response glioblastomas.