PPARG and familial pancreatic carcinoma: Several studieshave shown that PPARγ agonists, including the natural ligand 15-deoxy-Δ12,14-prostaglandin J2, and thiazolidinedione antidiabetic agents, such as citiglitizoneand rosiglitizone, inhibit growth and induce apoptosis in pancreatic cancer [75, 77–81].