There is evidence that pDCs arelocated in several types of tumors: head and neck cancer, ovarian cancer,primary melanoma cancer, and breast cancer [42–46, 75].Secreted factors by tumor cells may inhibit pDCs function, such as TGFβ,vascular endothelial growth factor β (VEGFβ), and IL-10. The gene discussed is IL10; the disease is neoplasm.