TIMP1 and systemic sclerosis: Fibroblasts derived from patients with SScproduce increased amounts of TIMP-1, TIMP-2, and TIMP-3 [6, 7], whereasexpression of MMP-1, MMP-2, and MMP-3 genes is decreased in fibroblasts frompatients with early SSc compared to fibroblasts from healthy individuals orpatients with late-stage disease [6].