TIMP-4 levelsdiffered significantly between SSc patients, when as criterion for abnormallyelevated PASP the level of 50 mm Hg (2880 ± 1174 pg/mL, n = 13, versus 1916 ± 998 pg/mL, P = .002), or the level of45 mm Hg(2586 ± 1283 pg/mL, n = 23versus 1882 ±948 pg/mL, P = .02) was considered. The gene discussed is CPB1; the disease is systemic sclerosis.