IGF-1 stimulates cell proliferation and differentiation, inhibits apoptosis (Kaaks and Lukanova, 2001; Gnagnarella et al, 2008) and increases production of vascular endothelial growth factors, important in tumour angiogenesis, and the expression of glucose transporters, glycolytic enzymes, and growth factors, which may promote tumor cell survival under hypoxic conditions (Akakura et al, 2001; Oh et al, 2008). This evidence concerns the gene IGF1 and neoplasm.