Therefore, to determine whether genes involved in cancer-specific recurrent translocations exhibit properties of fragile sites, we analyzed three gene pairs from Table 1 (CBFB/MYH11, HMGA1/LAMA4, and MLL/AFF4), and their flanking sequences, for flexibility, A/T content, and the propensity to form stable secondary structures. Here, LAMA4 is linked to cancer.