CALCOCO1 and metastatic neoplasm: His52Arg in NCOR2 was also found to be significantly positively associated regional/metastatic breast cancer (OR = 2.25; 95% CI, 1.15–4.38) while Arg12His in CALCOCO1 was more closely associated with ER-positive breast cancer (OR = 2.83; 95% CI, 1.19–6.74) and regional/metastatic disease (OR = 3.19; 95% CI, 1.12–9.11).