In order to further evaluate the effects of common inherited variation in the dopamine pathway on BMI, we extended our study to include four polymorphisms in the gene that codes for the dopamine transporter (DAT1), SLC6A3, among 2,364 participants in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. The gene discussed is SLC6A3; the disease is cancer.