This involvement would be consistent with the increased frequency of myopia in patients with open-angle glaucoma [18-20], the observation (though only in a proportion of studies) that intraocular pressure (IOP) is higher in myopes than in emmetropes [21], and the identification of significant genetic linkage close to the MYOC locus on chromosome 1 in families with myopia from the Beaver Dam Eye Study [22]. The gene discussed is MYOC; the disease is open-angle glaucoma.