To unequivocally demonstrate that the CRP∶L-ficolin interaction is triggered by infection-inflammation condition, we showed that the L-rFBG interacts avidly with CRP (Figure 5A) at KD of 1.26×10−8 M under infection-inflammation condition compared to 1.11×10−6 M under normal condition (Figure 5C and 5D). Here, CRP is linked to infection.