A low copy number of the CCL3L1-containing segmental duplication was shown to be associated with or correlate with an increased risk of acquiring HIV infection [12]–[17], a faster rate of progression to AIDS or CD4+ T cell depletion [12],[16],[18],[19], higher HIV viral loads [12],[13],[20], lower HIV-specific immune responses [20], and lower cell-mediated immune responses [18]. This evidence concerns the gene CCL3L3 and HIV infectious disease.