CORT and congenital rubella syndrome: Moreover, this hormetic dose response relationship may help explain the paradoxical finding that, while both CRS and chronic CORT each separately cause shrinkage of dendrites of CA3 neurons via a process dependent on glutamate release, the combination of CRS plus chronic CORT treatment, which presumptively elevates CORT levels beyond those produced by either treatment alone, prevented the dendritic remodeling [39].