Numerous human tumor antigens have been discovered using the above approaches, covering shared tumor-specific antigens (MAGE, NY-ESO-1, etc), antigens resulting from mutations (MUM-1, CDK4, etc.), differentiation antigens (MART-1, gp100), overexpressed antigens (p53, HER2/neu), and viral antigens (EBV, HPV16). This evidence concerns the gene PMEL and neoplasm.